Bénédicte Chazaud – PGNM

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Nourhane Bouchema

About

Bench revolution: Macrophages that switch color depending on their inflammatory status
Muscle homeostasis maintenance: With beer… and a bit of skiing and hiking!
Favorite saying: N’importe quoi ! (Nonsense!)

Events

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Cellular dynamics of muscle regeneration

Gabrielle Kardon

Abstract The function of many organs, including skeletal muscle, depends on its three-dimensional structure. Muscle regeneration therefore requires not only […]

Amphi Lacassagne

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Unravelling the PARamount role of NAD+-metabolism and PARylation in skeletal muscle and satellite cell health

Abstract Poly-ADP-Ribose Polymerases (PARPs) are a family of proteins that consume nicotinamide adenine dinucleotide (NAD+; a form of Vitamin B3) […]

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Immunotherapies for myocardial infarction

Dr Jean-Sébastien Sylvestre

Abstract Despite improved in the management, patients with ischemic heart failure still suffer from high morbidity and mortality, and there […]

Salle des Pas Perdus

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Study of skeletal muscle resident macrophages during regeneration after exercise-induced muscle damage

Thesis under embargo

News

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CNRS podcast with Bénédicte Chazaud

With What are you looking for?, the CNRS science podcast, meet scientists and discover their work. In this episode, Bénédicte […]

Projects

Muscle stem cell neighboring

Principal investigator Bénédicte Chazaud

Team: Stem cell environment and skeletal muscle homeostasis

Publications

Andreana I, Ghosh A, Repellin M, Kneppers A, Ben Larbi S, Tifni F, Fessard A, Martin M, Sidi-Boumedi..., Nanoparticle delivery of AMPK activator 991 prevents its toxicity and improves muscle homeostasis in Duchenne muscular dystrophy., Mol Ther Methods Clin Dev 2025 Sep; 33(3): 101564.

Jomard C, Boyer N, Fessard A, Chazaud B, Gondin J, Effect of analgesic treatments on voluntary activity, mechanical sensitivity and muscle regeneration after cardiotoxin injection in mice., Sci Rep 2025 Jul; 15(1): 27921.

Aurélie Fessard, Aliki Zavoriti, Natacha Boyer, Jules Guillemaud, Masoud Rahmati, Peggy del Carmine..., Neuromuscular electrical stimulation training induces myonuclear accretion and hypertrophy in mice without overt signs of muscle damage and regeneration, Skeletal Muscle, 2025, 15, ⟨10.1186/s13395-024-00372-0⟩.

Mázala DAG, Hindupur R, Moon YJ, Shaikh F, Gamu IH, Alladi D, Panci G, Weiss-Gayet M, Chazaud B, Pa..., Altered muscle niche contributes to myogenic deficit in the D2-mdx model of severe DMD., Cell Death Discov 2023 Jul; 9(1): 224.

Clara Bernard, Charline Jomard, Bénédicte Chazaud, Julien Gondin, Kinetics of skeletal muscle regeneration after mild and severe muscle damage induced by electrically‐evoked lengthening contractions, FASEB Journal, 2023, 37 (9), pp.e23107. ⟨10.1096/fj.202201708rr⟩.

Mura M, Weiss-Gayet M, Della-Schiava N, Chirico E, Lermusiaux P, Chambion-Diaz M, Faes C, Boreau A, ..., Monocyte Phenotypes and Physical Activity in Patients with Carotid Atherosclerosis., Antioxidants (Basel) 2022 Aug; 11(8): .

Chazaud B, Inflammation and Skeletal Muscle Regeneration: Leave It to the Macrophages!, Trends Immunol 2020 Jun; 41(6): 481-492.

Saclier M, Theret M, Mounier R, Chazaud B, Effects of Macrophage Conditioned-Medium on Murine and Human Muscle Cells: Analysis of Proliferation, Differentiation, and Fusion., Methods Mol Biol 2017 ; 1556(): 317-327.

Varga T, Mounier R, Patsalos A, Gogolák P, Peloquin M, Horvath A, Pap A, Daniel B, Nagy G, Pintye E..., Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration., Immunity 2016 Nov; 45(5): 1038-1051.

Weiss-Gayet M, Starck J, Chaabouni A, Chazaud B, Morlé F, Notch Stimulates Both Self-Renewal and Lineage Plasticity in a Subset of Murine CD9High Committed Megakaryocytic Progenitors., PLoS One 2016 ; 11(4): e0153860.