Diabetes-induced skeletal muscle fibrosis: Fibro-adipogenic precursors at work.

Publication details

Overview

Citation, authorship and indexing details for this publication.

Journal Article

Published

Authors

Chazaud B, Mounier R

Journal

Cell Metab 2021 Nov; 33(11): 2095-2096

Cell metabolism

DOI

10.1016/j.cmet.2021.10.009

Open DOI

PMID

34731650

Open PubMed

ISSN

1932-7420

Scientific fields

contraction macrophages microenvironment muscle stem cells myopathies skeletal muscle vessels

Members

Julien Gondin

Teams

Stem cell environment and skeletal muscle homeostasis

Summary

Skeletal muscle fibrosis is a complication of diabetes and insulin resistance. In this issue of Cell Metabolism, Farup et al. (2021) characterized fibro-adipogenic precursors (FAPs) in human skeletal muscle and showed that a CD34+CD90+ FAP subset is involved in diabetes-induced muscle fibrosis through PDGFRα signaling and activation of glycolysis.