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The team develops a series of research topics dedicated to the maintenance of skeletal muscle homeostasis. Some discoveries and techniques developed by the team have direct implications for the diagnostic or the treatment of neuromuscular disorders. The team hosts clinicians that are involved in research projects aimed at developing innovative biomarkers and understanding the pathophysiology of neuromuscular disorders.

PROJECTS

MUSCLE STEM CELLS

Epigenetic regulation of muscle stem cell fate (Leader: Dr. Isabella Scionti)

MUSCLE FIBERS

Histone variants (Leader: Dr. Edwige Belotti)

TGFβ signaling (Leader: Dr. Laetitia Mazelin)

mTOR signaling (Leader: Dr. Yann-Gaël Gangloff)

HDAC6 (Leader: Dr. Alexis Osseni)

MOTOR NEURON AND NEURO MUSCULAR JUNCTION

Protein misfolding disorders (Leader: Dr. Pascal Leblanc)

Motoneuron and NMJ genetic diseases: (Leader: Dr. Arnaud Jacquier)