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Our team aims to understand, in the model of skeletal muscle fibers, mechanisms controlling genome expression, cytoskeleton rearrangements and nuclear domain establishment and their implication in pathological contexts such as genetic disorders (Emery-Dreifuss Muscular Dystrophy and Centronuclear myopathies) or physiological aging (Sarcopenia). We also aim, in the model of cardiomyocyte, decipher implication of mutations identified in cardiomyopathies such as inherited hypertrophic cardiomyopathies (HCM), Atrial fibrillation (AF) or Arrhythmogenic right ventricular cardiomyopathy (ARVC).

PROJECTS

Evolution of the microtubule proteome and its involvement in the formation and maintenance of nuclear domains (MNDs) during skeletal muscle development (Leader: Dr. Vincent Gache)

Deciphering the signaling pathways regulated by the primary cilium in muscle stem cells (Leader: Dr. Caroline Brun)

Mechanisms of membrane trafficking in differentiated cells (Leader: Dr. G Boncompain)

Mutations identification and implication in the physiopathology of cardiomyopathies (Leader: Dr. V. Gache, Pr. Abitbol, Pr. Chevalier, Dr. Janin)