Striated Muscle Metabolic Cross-Talk in Health and Disease – PGNM

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Fundamental and pathophysiological mechanisms implicated in ataxia

Chromatin dynamics, nuclear domains, virus

About

Mechanisms controlling muscle maintenance and regeneration, and their role in the development of muscle diseases are not yet fully known. Metabolism is a key factor exerting a tight coordination between organelles, cell types, and tissues to support muscle homeostasis. Our team aims to identify the role of metabolic cross-talk in striated muscle maintenance in physiological and pathophysiological conditions with a multi-scale approach; encompassing 1) the cellular level, addressing the cross-talk between (metabolic) organelles within and between muscle cells; 2) the organ level, addressing the cross-talk between cells via alterations in local (metabolic) microenvironment; and 3) the organism level, addressing the cross-talk between different organ systems via alterations in the systemic (metabolic) environment.

Members

Research Assistant

Sabrina Ben Larbi

Research Assistant

Ioanna Beriatou

Lauréline Boutonnet

Engineer assistant

Nazanine Modjtahedi

Senior Researcher

Research Assistant

Léa Chaintreuil

Events

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We are pleased to welcome Ange Maguy from the Faculty of Medicine, University of Bern, Switzerland, and Stéphane Camus from […]

Amphi 3 Faculté de Médecine Lyon-Est Rockefeller

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Preclinical development of mitochondrial enhancing therapies in muscle disorders

Christopher Perry

Amphi Carraz (Faculté de Médecine Lyon-Est Rockefeller)

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Intrinsic Control and Lineage Plasticity of Pax7+ Muscle Progenitors

Philippos Mourikis

Abstract Muscle stem cells rely on a finely tuned niche to preserve their quiescent state and long-term regenerative capacity. The […]

Amphi Hermann (1st floor), Faculté de Médecine Lyon-Est Rockefeller

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Collagen disorders: is a one-for-all treatment fantasy?

Tom van Agtmael

Tom van Agtmael investigates how mutations in collagen proteins cause disease with the aim of developing effective treatments, using approaches […]

Amphi 3 (Faculté de Médecine Lyon-Est Rockefeller)

News

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Bronze Medal – 2018 INSB Laureate

Rémi Mounier is a 2018 CNRS Bronze Medal laureate.

Projects

Metabolic regulations of adult muscle stem cell fate

Principal investigator Rémi Mounier

Team: Striated Muscle Metabolic Cross-Talk in Health and Disease

A single nucleus approach solving the role of MuSCs in myofiber rejuvenation

Principal investigator Rémi Mounier

Principal investigator Anita Kneppers

Team: Striated Muscle Metabolic Cross-Talk in Health and Disease

Resistance of skeletal muscle to the metastatic process

Principal investigator Rémi Mounier

Principal investigator Anita Kneppers

Team: Striated Muscle Metabolic Cross-Talk in Health and Disease

Publications

Andreana I, Ghosh A, Repellin M, Kneppers A, Ben Larbi S, Tifni F, Fessard A, Martin M, Sidi-Boumedi..., Nanoparticle delivery of AMPK activator 991 prevents its toxicity and improves muscle homeostasis in Duchenne muscular dystrophy., Mol Ther Methods Clin Dev 2025 Sep; 33(3): 101564.

Delia Cicciarello, Sandrine Mouradian, Mélodie Pitchecanin, William Jarassier, Anita Kneppers, Rém..., The AMPKα2/PHF2 axis is critical for turning over lipid droplets during muscle stem cell fate, BioRxiv.

Saugues A, Kneppers A, Mounier R, [Muscle stem cells and metabolism in Duchenne muscular dystrophy, focus on AMPK]., Med Sci (Paris) 2024 Nov; 40 Hors série n° 1(): 60-63.

Mylène Fefeu, Michael Blatzer, Anita Kneppers, David Briand, Pierre Rocheteau, Alexandre Haroche, D..., Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice, Nature Communications.

Espino-Gonzalez E, Dalbram E, Mounier R, Gondin J, Farup J, Jessen N, Treebak JT, Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments., Cell Metab 2024 Jun; 36(6): 1204-1236.

Marine Lanfranchi, Sozerko Yandiev, Géraldine Meyer-Dilhet, Salma Ellouze, Martijn Kerkhofs, Raphae..., The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions, Nature Communications.

Osseni A, Ravel-Chapuis A, Belotti E, Scionti I, Gangloff YG, Moncollin V, Mazelin L, Mounier R, Leb..., Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation., Nat Commun 2022 Nov; 13(1): 7108.

Gaëtan Juban, Rémi Mounier, Réparation tissulaire : le rôle clé de l’annexine A1 dans le contrôle de la réaction inflammatoire, Médecine/Sciences.

Vincent Pialoux, Rémi Mounier, Julien V. Brugniaux, Hemoglobin and hematocrit are not such good candidates to detect autologous blood doping, International Journal of Hematology.