STRUCTURE AND DYNAMICS OF A 197 BP NUCLEOSOME IN COMPLEX WITH LINKER HISTONE H1
Bednar J, Garcia-Saez I, Boopathi R, Cutter AR, Papai G, Reymer A, Syed SH, Lone IN, Tonchev O, Crucifix C, Menoni H, Papin C, Skoufias DA, Kurumizaka H, Lavery R, Hamiche A*, Hayes JJ*, Schultz P*, Angelov D*, Petosa C*, Dimitrov S*
Cryo-EM and crystal structures of the nucleosome bound to histone H1 were determined. H1 binding induces the nucleosome to adopt a more compact and rigid conformation. The H1 globular domain interacts with core DNA on the dyad and with both DNA linkers. The H1 C-terminal domain associates primarily with a single DNA linker.
