Institut NeuroMyoGène
    Laboratoire Physiopathologie et Génétique du Neurone et du Muscle
    CNRS UMR 5261 -INSERM U1315
    Université de Lyon - Université Claude Bernard Lyon 1
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CHROMATIN DYNAMICS, NUCLEAR DOMAINS, VIRUS

  • The major research interests of the team LOMONTE are:
      • The study of the pathological consequences of the infection of neurons from the peripheral and central nervous systems by the neurotropic virus herpes simplex virus 1 (HSV-1). We essentially focus our research on the establishment of latency and reactivation processes.
      • The study of the implication of nuclear architecture, especially promyelocytic leukemia nuclear bodies (PML NBs), in the regulation of latent HSV-1 chromatin features and in chromatin dynamics during the process of senescence.
      • The study of the chromatin alterations associated to damage or to genetic pathologies, and potentially linked to genetic instabilities, or motoneurons decay.

SITES.GOOGLE.COM/SITE/LOMONTELAB/  

Chromatin assembly/damagePML and Cajal nuclear bodies Centromeres HSV-1 ICP0
TEAM
  • Patrick LOMONTE
    SENIOR RESEARCHER CNRS
  • Faouzi BAKLOUTI
    SENIOR RESEARCHER INSERM
  • Wilhelm BOUCHEREAU
    POST-DOC
  • Florent BRESSAC
    PHD STUDENT
  • Armelle CORPET
    ASSISTANT PROFESSOR UCBL
  • Tristan ESCURE
    PHD STUDENT
  • Clémence GUERRIAU
    RESEARCH ASSISTANT
  • Franceline JUILLARD
    POST-DOC
  • Karine MONIER
    RESEARCH ENGINEER CNRS
  • Delphine PONCET
    ASSISTANT PROFESSOR
  • Corentin ROUSSET
    RESEARCH ASSISTANT CNRS (CDD)
  • Coline SEURRE
    RESEARCH ASSISTANT
  • Hana TRIKI
    POST-DOC
ALUMNI
  • Simon ROUBILLE
    PHD STUDENT
  • Pascale TEXIER
    RESEARCH ASSISTANT CNRS
  • Remy NEPLAZ
    Master 2 student
  • Olivier BINDA
    POST-DOC
  • Clément DROILLARD
    POST-DOC
  • Constance KLEIJWEGT
    PHD STUDENT
  • Emeline TURQUER
    Master 2 STUDENT
  • Aleth CALLE
    Research Assistant
  • Camille COHEN
    PhD student
  • Indri ERLIANDRI
    Post-Doc
  • Karine JACQUET
    Post-Doc
  • Aimé-Boris KIMENYI-ISHIMWE
    Master 2 Student
  • Mohamed-Ali MAROUI
    Post-doc

Projects
Publications
Funding
Contact
Directory

PROJECTS

Beside the study of the biology of HSV-1, one of the main focus of the team is to understand, at the molecular level and using HSV-1 as a model, some basic aspects of nuclear and chromatin dynamics related to the maintenance of genome integrity and to the regulation of gene expression. (See web site for more details)


SELECTED PUBLICATIONS
  • Binda, O., Kimenyi Ishimwe, AB., Galloy, M., Jacquet, K., Corpet, A., Fradet-Trucotte, A., Côté, J., and Lomonte, P. (2023). The TUDOR domain of SMN is an H3K79 me1 histone mark reader Life Sci Alliance 6:e202201752. doi:10.26508/lsa.202201752
  • Binda, O., Juillard, F., Ducassou J.N., Kleijwegt, C., Paris G., Didillon A., Baklouti F., Corpet, A., Couté, Y., Côté, J. and Lomonte, P. (2023). SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members. Life Sci Alliance 6:e202201429. doi:10.26508/lsa.202201429
  • Jacquier A, Roubille S, Lomonte P, Schaeffer L. (2022). Microrchidia CW-Type Zinc Finger 2, a Chromatin Modifier in a Spectrum of Peripheral Neuropathies. Front Cell Neurosci. Jun 3;16:896854. doi: 10.3389/fncel.2022.896854. eCollection 2022.
  • Rousseau A, Haigh O, Legrand R, Palgen JL, Lemaitre J, Deback C, Oziol N, Lomonte P, Labetoulle M. (2022). Initial TK-deficient HSV-1 infection in the lip alters contralateral lip challenge immune dynamics. Sci Rep. May 19;12(1):8489. doi: 10.1038/s41598-022-12597-4.
  • Billard P, Guerriau C, Carpentier C, Juillard F, Grandin N, Lomonte P, Kantapareddy P, Dufay N, Barritault M, Rimokh R, Verrelle P, Maucort-Boulch D, Figarella-Branger D, Ducray F, Dehais C, Charbonneau M, Meyronet D, Poncet DA; POLA network. (2021). The TeloDIAG: how telomeric parameters can help in glioma rapid diagnosis and liquid biopsy approaches. Ann Oncol. Dec;32(12):1608-1617. doi: 10.1016/j.annonc.2021.09.004.
  • Corpet, A., Kleijwegt, C., Roubille, S., Juillard, F., Jacquet, K., Texier, P., and Lomonte, P. (2020). PML nuclear bodies and chromatin dynamics: catch me if you can! Nucleic Acids Research 389, 251–23
  • Lomonte, P., Baklouti, F., & Binda, O. (2020). The Biochemistry of Survival Motor Neuron Protein Is Paving the Way to Novel Therapies for Spinal Muscle Atrophy. Biochemistry. Apr14;59(14):1391-1397.
  • Marcocci ME, Napoletani G, Protto V, Kolesova O, Piacentini R, Li Puma DD, Lomonte P, Grassi C, Palamara AT, De Chiara G. (2020). Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection. Trends in Microbiology. 1-13.
  • Cohen, C., Corpet, A., Maroui, M.A., Juillard, F., and Lomonte, P. (2020). Latent/Quiescent Herpes Simplex Virus 1 Genome Detection by Fluorescence In Situ Hybridization (FISH). Methods Mol. Biol. 2060, 185–197.
  • Provost A., Rousset C.,, Bourdon L., Mezhoud S., Reungoat E., Fourneaux C., Bresson T., Pauly M., Béard N., Possi-Tchouanlong L., Grigorov B., Bouvet P., Diaz J.J., Chamot C., Pécheur E.-I., Ladavière C. *, Charreyre M.-T. *, Favier A., Place C.*, Monier K. *. (2019). Innovative particle standards and long-lived imaging for 2D and 3D dSTORM. Sci. Rep. 9(1):17967
  • Grandin N, Pereira B, Cohen C, Billard P, Dehais C, Carpentier C, Idbaih A, Bielle F, Ducray F, Figarella-Branger D, Delattre JY, Sanson M, Lomonte P, Poncet D, Verrelle P, Charbonneau M; POLA network. (2019). The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas.Acta Neuropathol Commun. 7, 175.
  • Cohen, C., Corpet, A., Roubille, S., Ali Maroui, M.A., Poccardi, N., Rousseau, A., Kleijwegt, C., Binda, O., Texier, P., Sawtell, N., Labetoulle, M., and Lomonte, P. (2018). Promyelocytic Leukemia (PML) Nuclear Bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone axis. Plos Pathogens 14(9): e1007313.

 


FUNDING
  • CNRS prematuration program: dSTORM imaging in the green channel to reconstruct 3 colors and 3D in super-resolution dSTORM (18 months)
  • ANR CHROMACoV (ANR-20-COV9-0004)
  • ANR EPIPRO (ANR-18-CE15-0014-01)
  • LabEX DEV2CAN (ANR-10-LABX-61)
  • LabEX DEVweCAN (ANR-10-LABX-61)
  • AFM-Téléthon / MyoNeurALP Alliance (2016-2021)
  • France Alzheimer
  • Fondation pour la Recherche Médicale (FRM)
  • Ligue Contre le Cancer (Comité du Rhône)
  • UCBL: CNMD (Ottawa, Canada)-INMG Joint collaborative Research Program

 

             

Email

patrick.lomonte@univ-lyon1.fr

Phone

+33 4 26 68 82 57

Address

Institut NeuroMyoGène
UCBL – CNRS UMR 5310 – INSERM U1217
Faculté de Médecine et de Pharmacie – 3ème étage – Aile B
8 avenue Rockefeller
69008 Lyon
France


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