Institut NeuroMyoGène
    Laboratoire Physiopathologie et Génétique du Neurone et du Muscle
    CNRS UMR 5261 -INSERM U1315
    Université de Lyon - Université Claude Bernard Lyon 1
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LOMONTELOMONTELOMONTELOMONTE
  • PGNM
    • Presentation
    • Directory
    • Amenities
    • Platforms
      • PGNM Platforms
      • Platforms of the Rockefeller Site
  • Teams
    • BECCARI
    • BOMONT
    • CHAZAUD
    • COURCHET
    • GACHE
    • GIGLIA-MARI
    • JACQUEMOND
    • LE GRAND
    • LOMONTE
    • MOUNIER
    • PUCCIO
    • SCHAEFFER
  • Lab activities
    • External seminars
    • Internal seminars
    • Clubs
      • Chromatin
      • Metabolism
      • Neuromuscular Club
    • YRIN – Young Researchers INMG
    • Thesis
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    • Collaborations
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  • Education
    • Academic teaching
    • Public outreach
      • Les Cellules Déambulent / The Stroll Cells
      • Telethon ; Science Day
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      • Cell culture
  • Job offers
    • Jobs
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  • Publications
    • 2022
    • 2021
    • 2020
    • 2019
    • 2018
    • 2017
    • 2016

CHROMATIN ASSEMBLY, NUCLEAR DOMAINS, VIRUS

  • The major research interests of the team LOMONTE are:
      • The study of the pathological consequences of the infection of neurons from the peripheral and central nervous systems by the neurotropic virus herpes simplex virus 1 (HSV-1). We essentially focus our research on the establishment of latency and reactivation processes.
      • The study of the implication of nuclear architecture, especially promyelocytic leukemia nuclear bodies (PML NBs), in the regulation of latent HSV-1 chromatin features and in chromatin dynamics during the process of senescence.
      • The study of the chromatin alterations associated to damage or to genetic pathologies, and potentially linked to genetic instabilities, or motoneurons decay.

SITES.GOOGLE.COM/SITE/LOMONTELAB/  

Chromatin assembly/damagePML and Cajal nuclear bodies Centromeres HSV-1 ICP0
TEAM
  • Patrick LOMONTE
    SENIOR RESEARCHER CNRS
  • Faouzi BAKLOUTI
    SENIOR RESEARCHER INSERM
  • Wilhelm BOUCHEREAU
    POST-DOC
  • Florent BRESSAC
    PHD STUDENT
  • Armelle CORPET
    ASSISTANT PROFESSOR UCBL
  • Tristan ESCURE
    Master 2 student
  • Franceline JUILLARD
    POST-DOC
  • Karine MONIER
    RESEARCH ENGINEER CNRS
  • Simon ROUBILLE
    PHD STUDENT
  • Corentin ROUSSET
    RESEARCH ASSISTANT CNRS (CDD)
  • Hana TRIKI
    POST-DOC
ALUMNI
  • Pascale TEXIER
    RESEARCH ASSISTANT CNRS
  • Remy NEPLAZ
    Master 2 student
  • Olivier BINDA
    POST-DOC
  • Clément DROILLARD
    POST-DOC
  • Constance KLEIJWEGT
    PHD STUDENT
  • Emeline TURQUER
    Master 2 STUDENT
  • Aleth CALLE
    Research Assistant
  • Camille COHEN
    PhD student
  • Indri ERLIANDRI
    Post-Doc
  • Karine JACQUET
    Post-Doc
  • Aimé-Boris KIMENYI-ISHIMWE
    Master 2 Student
  • Mohamed-Ali MAROUI
    Post-doc

Projects
Publications
Funding
Contact
Directory

PROJECTS

Beside the study of the biology of HSV-1, one of the main focus of the team is to understand, at the molecular level and using HSV-1 as a model, some basic aspects of nuclear and chromatin dynamics related to the maintenance of genome integrity and to the regulation of gene expression. (See web site for more details)


SELECTED PUBLICATIONS
  • Jacquier A, Roubille S, Lomonte P, Schaeffer L. (2022). Microrchidia CW-Type Zinc Finger 2, a Chromatin Modifier in a Spectrum of Peripheral Neuropathies. Front Cell Neurosci. Jun 3;16:896854. doi: 10.3389/fncel.2022.896854. eCollection 2022.
  • Rousseau A, Haigh O, Legrand R, Palgen JL, Lemaitre J, Deback C, Oziol N, Lomonte P, Labetoulle M. (2022). Initial TK-deficient HSV-1 infection in the lip alters contralateral lip challenge immune dynamics. Sci Rep. May 19;12(1):8489. doi: 10.1038/s41598-022-12597-4.
  • Billard P, Guerriau C, Carpentier C, Juillard F, Grandin N, Lomonte P, Kantapareddy P, Dufay N, Barritault M, Rimokh R, Verrelle P, Maucort-Boulch D, Figarella-Branger D, Ducray F, Dehais C, Charbonneau M, Meyronet D, Poncet DA; POLA network. (2021). PML nuclear bodies and chromatin dynamics: catch me if you can! Ann Oncol. Dec;32(12):1608-1617. doi: 10.1016/j.annonc.2021.09.004.
  • Corpet, A., Kleijwegt, C., Roubille, S., Juillard, F., Jacquet, K., Texier, P., and Lomonte, P. (2020). PML nuclear bodies and chromatin dynamics: catch me if you can! Nucleic Acids Research 389, 251–23
  • Lomonte, P., Baklouti, F., & Binda, O. (2020). The Biochemistry of Survival Motor Neuron Protein Is Paving the Way to Novel Therapies for Spinal Muscle Atrophy. Biochemistry. Apr14;59(14):1391-1397.
  • Marcocci ME, Napoletani G, Protto V, Kolesova O, Piacentini R, Li Puma DD, Lomonte P, Grassi C, Palamara AT, De Chiara G. (2020). Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection. Trends in Microbiology. 1-13.
  • Cohen, C., Corpet, A., Maroui, M.A., Juillard, F., and Lomonte, P. (2020). Latent/Quiescent Herpes Simplex Virus 1 Genome Detection by Fluorescence In Situ Hybridization (FISH). Methods Mol. Biol. 2060, 185–197.
  • Provost A., Rousset C.,, Bourdon L., Mezhoud S., Reungoat E., Fourneaux C., Bresson T., Pauly M., Béard N., Possi-Tchouanlong L., Grigorov B., Bouvet P., Diaz J.J., Chamot C., Pécheur E.-I., Ladavière C. *, Charreyre M.-T. *, Favier A., Place C.*, Monier K. *. (2019). Innovative particle standards and long-lived imaging for 2D and 3D dSTORM. Sci. Rep. 9(1):17967
  • Grandin N, Pereira B, Cohen C, Billard P, Dehais C, Carpentier C, Idbaih A, Bielle F, Ducray F, Figarella-Branger D, Delattre JY, Sanson M, Lomonte P, Poncet D, Verrelle P, Charbonneau M; POLA network. (2019). The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas.Acta Neuropathol Commun. 7, 175.
  • Cohen, C., Corpet, A., Roubille, S., Ali Maroui, M.A., Poccardi, N., Rousseau, A., Kleijwegt, C., Binda, O., Texier, P., Sawtell, N., Labetoulle, M., and Lomonte, P. (2018). Promyelocytic Leukemia (PML) Nuclear Bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone axis. Plos Pathogens 14(9): e1007313.
  • Herpesvirus latency: On the importance of positioning oneself
    Lomonte P. Advances in Anatomy, Embryology and Cell Biology. Cell Biology of Herpes Viruses. Ed. Springer Nature (2017) vol. 223, pp95–117.
  • The interaction between herpes simplex virus 1 genome and promyelocytic leukemia nuclear bodies (PML-NBs) as a hallmark of the entry in latency
    Lomonte P. Microbial Cell (2016) vol. 3 (11), pp. 438-441.
  • Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment
    Maroui M-A*, Callé A*, Cohen C, Streichenberger N, Texier P, Takissian J, Rousseau A, Poccardi N, Welsch J, Corpet A, Schaeffer L, Labetoulle M, Lomonte P. Plos Pathogens (2016) 12: e1005834.
  • Real-time tracking ofparental histones reveals their contribution to chromatin integrity followingDNA damage
    Adam S, Dabin J, Chevallier O, Leroy O, Baldeyron C, Corpet A, Lomonte P, Renaud O, Almouzni G, Polo SE. Molecular Cell (2016) vol. 64 (1) pp. 65-78.

 


FUNDING
  • CNRS prematuration program: dSTORM imaging in the green channel to reconstruct 3 colors and 3D in super-resolution dSTORM (18 months)
  • ANR CHROMACoV (ANR-20-COV9-0004)
  • ANR EPIPRO (ANR-18-CE15-0014-01)
  • LabEX DEV2CAN (ANR-10-LABX-61)
  • LabEX DEVweCAN (ANR-10-LABX-61)
  • AFM-Téléthon / MyoNeurALP Alliance (2016-2021)
  • France Alzheimer
  • Fondation pour la Recherche Médicale (FRM)
  • Ligue Contre le Cancer (Comité du Rhône)
  • UCBL: CNMD (Ottawa, Canada)-INMG Joint collaborative Research Program

 

             

Email

patrick.lomonte@univ-lyon1.fr

Phone

+33 4 26 68 82 57

Address

Institut NeuroMyoGène
UCBL – CNRS UMR 5310 – INSERM U1217
Faculté de Médecine et de Pharmacie – 3ème étage – Aile B
8 avenue Rockefeller
69008 Lyon
France


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