PROJECTS

Beside the study of the biology of HSV-1, one of the main focus of the team is to understand, at the molecular level and using HSV-1 as a model, some basic aspects of nuclear and chromatin dynamics related to the maintenance of genome integrity and to the regulation of gene expression. (See web site for more details)

SELECTED PUBLICATIONS

• Binda, O., Kimenyi Ishimwe, AB., Galloy, M., Jacquet, K., Corpet, A., Fradet-Trucotte, A., Côté, J., and Lomonte, P. (2023). The TUDOR domain of SMN is an H3K79 me1 histone mark reader Life Sci Alliance 6:e202201752. doi:10.26508/lsa.202201752
• Binda, O., Juillard, F., Ducassou J.N., Kleijwegt, C., Paris G., Didillon A., Baklouti F., Corpet, A., Couté, Y., Côté, J. and Lomonte, P. (2023). SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members. Life Sci Alliance 6:e202201429. doi:10.26508/lsa.202201429
• Jacquier A, Roubille S, Lomonte P, Schaeffer L. (2022). Microrchidia CW-Type Zinc Finger 2, a Chromatin Modifier in a Spectrum of Peripheral Neuropathies. Front Cell Neurosci. Jun 3;16:896854. doi: 10.3389/fncel.2022.896854. eCollection 2022.
• Rousseau A, Haigh O, Legrand R, Palgen JL, Lemaitre J, Deback C, Oziol N, Lomonte P, Labetoulle M. (2022). Initial TK-deficient HSV-1 infection in the lip alters contralateral lip challenge immune dynamics. Sci Rep. May 19;12(1):8489. doi: 10.1038/s41598-022-12597-4.
• Billard P, Guerriau C, Carpentier C, Juillard F, Grandin N, Lomonte P, Kantapareddy P, Dufay N, Barritault M, Rimokh R, Verrelle P, Maucort-Boulch D, Figarella-Branger D, Ducray F, Dehais C, Charbonneau M, Meyronet D, Poncet DA; POLA network. (2021). The TeloDIAG: how telomeric parameters can help in glioma rapid diagnosis and liquid biopsy approaches. Ann Oncol. Dec;32(12):1608-1617. doi: 10.1016/j.annonc.2021.09.004.
• Corpet, A., Kleijwegt, C., Roubille, S., Juillard, F., Jacquet, K., Texier, P., and Lomonte, P. (2020). PML nuclear bodies and chromatin dynamics: catch me if you can! Nucleic Acids Research 389, 251–23
• Lomonte, P., Baklouti, F., & Binda, O. (2020). The Biochemistry of Survival Motor Neuron Protein Is Paving the Way to Novel Therapies for Spinal Muscle Atrophy. Biochemistry. Apr14;59(14):1391-1397.
• Marcocci ME, Napoletani G, Protto V, Kolesova O, Piacentini R, Li Puma DD, Lomonte P, Grassi C, Palamara AT, De Chiara G. (2020). Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection. Trends in Microbiology. 1-13.
• Cohen, C., Corpet, A., Maroui, M.A., Juillard, F., and Lomonte, P. (2020). Latent/Quiescent Herpes Simplex Virus 1 Genome Detection by Fluorescence In Situ Hybridization (FISH). Methods Mol. Biol. 2060, 185–197.
• Provost A., Rousset C.,, Bourdon L., Mezhoud S., Reungoat E., Fourneaux C., Bresson T., Pauly M., Béard N., Possi-Tchouanlong L., Grigorov B., Bouvet P., Diaz J.J., Chamot C., Pécheur E.-I., Ladavière C. *, Charreyre M.-T. *, Favier A., Place C.*, Monier K. *. (2019). Innovative particle standards and long-lived imaging for 2D and 3D dSTORM. Sci. Rep. 9(1):17967
• Grandin N, Pereira B, Cohen C, Billard P, Dehais C, Carpentier C, Idbaih A, Bielle F, Ducray F, Figarella-Branger D, Delattre JY, Sanson M, Lomonte P, Poncet D, Verrelle P, Charbonneau M; POLA network. (2019). The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas.Acta Neuropathol Commun. 7, 175.
• Cohen, C., Corpet, A., Roubille, S., Ali Maroui, M.A., Poccardi, N., Rousseau, A., Kleijwegt, C., Binda, O., Texier, P., Sawtell, N., Labetoulle, M., and Lomonte, P. (2018). Promyelocytic Leukemia (PML) Nuclear Bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone axis. Plos Pathogens 14(9): e1007313.

FUNDING

• CNRS prematuration program: dSTORM imaging in the green channel to reconstruct 3 colors and 3D in super-resolution dSTORM (18 months)
• ANR CHROMACoV (ANR-20-COV9-0004)
• ANR EPIPRO (ANR-18-CE15-0014-01)
• LabEX DEV2CAN (ANR-10-LABX-61)
• LabEX DEVweCAN (ANR-10-LABX-61)
• AFM-Téléthon / MyoNeurALP Alliance (2016-2021)
• France Alzheimer
• Fondation pour la Recherche Médicale (FRM)
• Ligue Contre le Cancer (Comité du Rhône)
• UCBL: CNMD (Ottawa, Canada)-INMG Joint collaborative Research Program