Institut NeuroMyoGène
    Laboratoire Physiopathologie et Génétique du Neurone et du Muscle
    CNRS UMR 5261 -INSERM U1315
    Université de Lyon - Université Claude Bernard Lyon 1
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MACROPHAGE PPARGAMMA, A LIPID ACTIVATED TRANSCRIPTION FACTOR CONTROLS THE GROWTH FACTOR GDF3 AND SKELETAL MUSCLE REGENERATION.

Tamas Varga, Rémi Mounier, Andreas Patsalos, Péter Gogolák, Matthew Peloquin, Attila Horvath, Attila Pap, Bence Daniel, Gergely Nagy, Eva Pintye, Szilárd Poliska, Sylvain Cuvellier, Sabrina Ben Larbi, Brian E. Sansbury, Matthew Spite, Chester W. Brown, Bénédicte Chazaud, Laszlo Nagy

PPARγ is a lipid activated transcription factor essential for fat cells and linked to lipid processing in macrophages. Varga et al. (2016) now show that PPARγ is transcriptionally active and regulates the growth factor Gdf3 in repair macrophages in regenerating skeletal muscle, forming a paracrine axis connecting macrophages to muscle progenitor fusion.


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