Institut NeuroMyoGène
    Laboratoire Physiopathologie et Génétique du Neurone et du Muscle
    CNRS UMR 5261 -INSERM U1315
    Université de Lyon - Université Claude Bernard Lyon 1
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New publication from Gaëtan Juban (Bénédicte Chazaud’s Team)

 

Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation
McArthur S*, Juban G*, Gobbetti T,* Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP, Chazaud B, Perretti M*, Mounier R*.
J Clin Invest.2020 Feb 4. pii: 124635. doi: 10.1172/JCI124635

Our group identified Annexin A1 as a new molecular trigger of AMPK activation in macrophages during skeletal muscle regeneration. We showed that Annexin A1 is first produced by infiltrating neutrophils, binds its receptor FPR2 expressed by pro-inflammatory macrophages that activates AMPK and triggers macrophage skewing towards a pro-reparative phenotype.


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