We are very pleased to welcome Marta Zaninello from the University of Cologne in Germany on December 19th. She will give a seminar at 11.30 am entitled: “mRNA and metabolism: two keys for axonal translation”. The seminar will be in the Amphi Carraz, 1st floor, corridor C – D .
Abstract:
Axonal degeneration is a hallmark of aging, injury, and neurodegenerative diseases. Axonal integrity depends on local protein synthesis, which is regulated by proteins and metabolic status. While transcriptomic data offers insights into axonal molecular composition, the proteome is a better descriptor, as translation is non-linear. Recent advances in proteomics potentially enable the identification of novel proteins that modulate axonal function. This project focuses on identifying novel regulators of mRNA in axons and investigating their role in axonal metabolism and local translation.
Brief CV:
2018-present Post-doctoral researcher, University of Cologne, Germany
2015-2017 Post-doctoral researcher, VIMM, Padova, Italy
2010-2014 PhD fellow, University of Padova, Italy
2010 MSc Neuroscience, University of Trieste, Italy
Selected publications:
- Zaninello M, Schlegel T, Nolte H, Pirzada M, Savino E, Barth E, Klein I, Wüstenberg H, Uddin T, Wolff L, Wirth B, Lehmann HC, Cioni JM, Langer T, Rugarli EI. CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy. Sci Adv, 2024 May 31;10(22):eadn2050. doi: 10.1126/sciadv.adn2050.
- Iavarone I*, Zaninello M*, Perrone M, Monaco M, Barth E, Gaedke F, Pizzo M, Di Lorenzo G, Desiderio V, Sommella E, Merciai F, Salviati E, Campiglia P, Luongo L, De Leonibus E, Rugarli EI, Settembre C. Fam134c and Fam134b shape axonal endoplasmic reticulum architecture in vivo. EMBO Rep, 2024 Jul 22.;doi: 10.1038/s44319-024-00213-7. *Contributed equally.
- Zaninello M, Palikaras K, Naon D, Iwata K, Herkenne S, Quintana-Cabrera R, Semenzato M, Grespi F, Ross-Cisneros FN, Carelli V, Sadun AA, Tavernarakis N, Scorrano L. Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy. Nat Commun. 2020 Aug 12;11(1):4029. doi: 10.1038/s41467-020-17821-1.