Molecular Psychiatry

A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior.

De Rossi P, Harde E, Dupuis JP, Martin L, Chounlamountri N, Bardin M, Watrin C, Benetollo C, Pernet-Gallay K, Luhmann HJ, Honnorat J, Malleret G, Groc L, Acker-Palmer A, Salin PA, Meissirel C.

Increasing evidence indicate that the vascular endothelial growth factor (VEGF) can facilitate memory performances but its impact on synapses remains poorly understood. De Rossi et al. now show that VEGF exerts a direct effect on synapse structure and function through its receptor VEGFR2 on neurons. This VEGF-VEGFR2 pathway is required for hippocampal synaptic plasticity and consolidation of memory.


Phosphatidylinositol 3-kinase inhibition restores Ca2+ release defects and prolongs survival in myotubularin-deficient mice

Candice Kutchukian, Mirella Lo Scrudato, Yves Tourneur, Karine Poulard, Alban Vignaud, Christine Berthier, Bruno Allard, Michael W. Lawlor, Ana Buj-Bello, and Vincent Jacquemond

Myotubular myopathy is a fatal disease resulting from deficiency in the phosphoinositide phosphatase MTM1. Kutchukian et al. (2016) have now identified critical pathophysiological alterations of Ca2+ signaling which are involved in the disease and have revealed the benefit of a pharmacological treatment.

Molecular Cell

The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity.

Roulland Y, Ouararhni K, Naidenov M, Ramos L, Shuaib M, Syed SH, Lone IN, Boopathi R, Fontaine E, Papai G, Tachiwana H, Gautier T, Skoufias D, Padmanabhan K, Bednar J, Kurumizaka H, Schultz P, *Angelov D, *Hamiche A, *Dimitrov S.

CENP-A nucleosomal ends are highly flexible in solution, which prevents recruitment of the linker histone H1 thus allowing assembly of active kinetochore complex. Open CENP-A nucleosomal structure is essential for its mitotic function.

IMMUNITY   Communiqué de presse du CNRS   Science & santé

Macrophage PPARgamma, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration.

Tamas Varga, Rémi Mounier, Andreas Patsalos, Péter Gogolák, Matthew Peloquin, Attila Horvath, Attila Pap, Bence Daniel, Gergely Nagy, Eva Pintye, Szilárd Poliska, Sylvain Cuvellier, Sabrina Ben Larbi, Brian E. Sansbury, Matthew Spite, Chester W. Brown, Bénédicte Chazaud, Laszlo Nagy

PPARγ is a lipid activated transcription factor essential for fat cells and linked to lipid processing in macrophages. Varga et al. (2016) now show that PPARγ is transcriptionally active and regulates the growth factor Gdf3 in repair macrophages in regenerating skeletal muscle, forming a paracrine axis connecting macrophages to muscle progenitor fusion.

Chromatin associated mechanisms in base excision repair – nucleosome remodeling and DNA transcription, two key players.

Menoni H, Di Mascio P, Cadet J, Dimitrov S, Angelov D.

Free Radic Biol Med 2016 Dec 20. pii: S0891-5849(16)31126-1.

Evidence for ARGONAUTE4-DNA interactions in RNA-directed DNA methylation in plants.

Lahmy S, Pontier D, Bies-Etheve N, Laudié M, Feng S, Jobet E, Hale CJ, Cooke R, Hakimi MA, Angelov D, Jacobsen SE, Lagrange T.

Genes Dev 2016 Dec 1;30(23):2565-2570

Extra views on Structure and dynamics of DNA loops on nucleosomes studied with molecular simulations.

Pasi M, Angelov D, Bednar J, Dimitrov S, Lavery R

Nucleus 2016 Nov;7(6):554-559

Real-Time Tracking of Parental Histones Reveals Their Contribution to Chromatin Integrity Following DNA Damage.

Salomé Adam, Juliette Dabin, Odile Chevallier, Olivier Leroy, Céline Baldeyron, Armelle Corpet, Patrick Lomonte, Olivier Renaud, Geneviève Almouzni, and Sophie E. Polo

Molecular Cell 2016 Oct 6; 64(1): 65–78.

Treatment of Progressive Multifocal Leukoencephalopathy With Mirtazapine.

Jamilloux Y, Kerever S, Ferry T, Broussolle C, Honnorat J, Sève P.

Clin Drug Investig. 2016 Oct;36(10):783-9.

Cyclophosphamide-responsive Lgi1-related limbic encephalitis with basal ganglia hypermetabolism.

Renard D, Collombier L, Lippi A, Honnorat J, Thouvenot E.

Acta Neurol Belg. 2016 Sep;116(3):379-81.

Characterization of a Subtype of Autoimmune Encephalitis With Anti-Contactin-Associated Protein-like 2 Antibodies in the Cerebrospinal Fluid, Prominent Limbic Symptoms, and Seizures.

Joubert B, Saint-Martin M, Noraz N, Picard G, Rogemond V, Ducray F, Desestret V, Psimaras D, Delattre JY, Antoine JC, Honnorat J.

JAMA Neurol. 2016 Sep 1;73(9):1115-24.

Journal of Cell Biology

Transition zone assembly and its contribution to axoneme formation in Drosophila male germ cells

Jennifer Vieillard, Marie Paschaki, Jean-Luc Duteyrat, Céline Augière, Elisabeth Cortier, Jean-André Lapart, Joëlle Thomas, Bénédicte Durand

Ciliary transition zone (TZ) assembly is complex and incompletely understood. Vieillard et al. show that Drosophila Cby and Dila cooperate to assemble the TZ and membrane cap, which, together with microtubule remodeling by kinesin-13, is required for axoneme formation in male germ cells.

Extra views on Structure and dynamics of DNA loops on nucleosomes studied with molecular simulations.

Pasi M, Angelov D, Bednar J, Dimitrov S, Lavery R

Nucleus 2016 Nov 22

Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment.

Mohamed Ali Maroui, Aleth Callé , Camille Cohen, Nathalie Streichenberger, Pascale Texier, Julie Takissian, Antoine Rousseau, Nolwenn Poccardi, Jérémy Welsch, Armelle Corpet, Laurent Schaeffer, Marc Labetoulle, Patrick Lomonte

PLoS Pathogens 2016 Sep 12;12(9):e1005834

Commissural axon navigation: Control of midline crossing in the vertebrate spinal cord by the semaphorin 3B signaling.

Pignata A, Ducuing H, Castellani V.

Cell Adh Migr. 2016 Nov;10(6):604-617. Epub 2016 Aug 17.

Neuroleptic intolerance in patients with anti-NMDAR encephalitis.

Lejuste F, Thomas L, Picard G, Desestret V, Ducray F, Rogemond V, Psimaras D, Antoine JC, Delattre JY, Groc L, Leboyer M, Honnorat J.

Neurol Neuroimmunol Neuroinflamm. 2016 Aug 29;3(5):e280.

Anti-N-methyl-D-aspartate Receptor Encephalitis in Adult Patients Requiring Intensive Care.

de Montmollin E, Demeret S, Brulé N, Conrad M, Dailler F, Lerolle N, Navellou JC, Schwebel C, Alves M, Cour M, Engrand N, Tonnelier JM, Maury E, Ruckly S, Picard G, Rogemond V, Magalhaes É, Sharshar T, Timsit JF, Honnorat J, Sonneville R; ENCEPHALITICA study group.

Am J Respir Crit Care Med 2016 Aug 23

Development, structure, and maintenance of C. elegans body wall muscle,

Gieseler, K., Qadota,H., and Benian, G.M.

Wormbook 2016 August 23, 2016

The cost-effectiveness of tumor-treating fields therapy in patients with newly diagnosed glioblastoma.

Bernard-Arnoux F, Lamure M, Ducray F, Aulagner G, Honnorat J, Armoiry X.

Neuro Oncol 2016 Aug;18(8):1129-36.

mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis.

Laetitia Mazelin, Baptiste Panthu, Anne-Sophie Nicot, Edwige Belotti, Lionel Tintignac, Geoffrey Teixeira, Qing Zhang, Valérie Risson, Dominique Baas, Emilie Delaune, Geneviève Derumeaux, Daniel Taillandier, Théophile Ohlmann, Michel Ovize, Yann-Gaël Gangloff, Laurent Schaeffer

Journal of Molecular and Cellular Cardiology 2016 Aug;97:213-25.

FACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSC.

Charles Richard JL, Shukla MS, Menoni H, Ouararhni K, Lone IN, Roulland Y, Papin C, Ben Simon E, Kundu T, Hamiche A*, Angelov D*, Dimitrov S*

PLoS Genetics 2016 Jul 28;12(7):e1006221.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ et al.

Autophagy 2016 12(1):1-222.

Anti-NMDA receptor antibody encephalitis and neuroendocrine pancreatic tumor: Causal link?

Afanasiev V, Brechemier ML, Boisseau W, Ducoudray R, Mayeur ME, Meyronet D, Peskine A, Desestret V, Psimaras D.

Neurology 2016 Jul 5;87(1):112-3.

Preventing Illegitimate Extrasynaptic Acetylcholine Receptor Clustering Requires the RSU-1 Protein.

Pierron M, Pinan-Lucarré B, Bessereau JL.

Journal of Neuroscience 2016 Jun 15;36(24):6525-37.

Syk kinases are required for spinal commissural axon repulsion at the midline via the ephrin/Eph pathway.

Noraz N, Jaaoini I, Charoy C, Watrin C, Chounlamountri N, Benon A, Malleval C, Boudin H, Honnorat J, Castellani V, Pellier-Monnin V.

Development 2016 Jun 15;143(12):2183-93.

Highly Dynamic Transcriptional Signature of Distinct Macrophage Subsets during Sterile Inflammation, Resolution, and Tissue Repair.

Varga T, Mounier R, Horvath A, Cuvellier S, Dumont F, Poliska S, Ardjoune H, Juban G, Nagy L, Chazaud B.

Journal of Immunology 2016 Jun 1;196(11):4771-82.

NFκB is a central regulator of protein quality control in response to protein aggregation stresses via autophagy modulation.

Nivon M, Fort L, Muller P, Richet E, Simon S, Guey B, Fournier M, Arrigo AP, Hetz C, Atkin JD, Kretz-Remy C.

Mol Biol Cell. 2016 Jun 1;27(11):1712-27.

Differential Effects of PI3K and Dual PI3K/mTOR Inhibition in Rat Prolactin-Secreting Pituitary Tumors.

Chanal M, Chevallier P, Raverot V, Fonteneau G, Lucia K, Monteserin Garcia JL, Rachwan A, Jouanneau E, Trouillas J, Honnorat J, Auger C, Theodoropoulou M, Raverot G.

Molecular Cancer Therapeutics 2016 Jun;15(6):1261-70.

Neuronal central nervous system syndromes probably mediated by autoantibodies.

Chefdeville A, Honnorat J, Hampe CS, Desestret V.

European Journal of Neuroscience 2016 Jun;43(12):1535-52.

Prostate cancer, Hu antibodies and paraneoplastic neurological syndromes

Storstein A, Raspotnig M, Vitaliani R, Giometto B, Graus F, Grisold W, Honnorat J, Vedeler CA.

J Neurology 2016 May;263(5):1001-7.

Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis.

Daniel Sieiro, Anne C Rios, Claire E Hirst, Christophe Marcelle

Elife 2016 May 24;5. pii: e14847.

Notch Stimulates Both Self-Renewal and Lineage Plasticity in a Subset of Murine CD9High Committed Megakaryocytic Progenitors.

Weiss-Gayet M, Starck J, Chaabouni A, Chazaud B, Morlé F.

PLoS One 2016 Apr 18;11(4):e0153860.

A clinical approach to diagnosis of autoimmune encephalitis.

Graus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T, Cortese I, Dale RC, Gelfand JM, Geschwind M, Glaser CA, Honnorat J, Höftberger R, Iizuka T, Irani SR, Lancaster E, Leypoldt F, Prüss H, Rae-Grant A, Reindl M, Rosenfeld MR, Rostásy K, Saiz A, Venkatesan A, Vincent A, Wandinger KP, Waters P, Dalmau J.

Lancet Neurol. 2016 Apr;15(4):391-404.

New Findings in Adult Opsoclonus-Myoclonus Syndrome.

Jérôme Honnorat

JAMA Neurol. 2016 Apr;73(4):381-2.

Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias. Cerebellum

Mitoma H, Adhikari K, Aeschlimann D, Chattopadhyay P, Hadjivassiliou M, Hampe CS, Honnorat J, Joubert B, Kakei S, Lee J, Manto M, Matsunaga A, Mizusawa H, Nanri K, Shanmugarajah P, Yoneda M, Yuki N.

Cerebellum 2016 Apr;15(2):213-32.

Motor cortex and hippocampus are the two main cortical targets in LGI1-antibody encephalitis.

Navarro V, Kas A, Apartis E, Chami L, Rogemond V, Levy P, Psimaras D, Habert MO, Baulac M, Delattre JY, Honnorat J; collaborators.

Brain 2016 Apr;139(Pt 4):1079-93.

Integrated multi-omics analysis of oligodendroglial tumours identifies three subgroups of 1p/19q co-deleted gliomas.

Kamoun A, Idbaih A, Dehais C, Elarouci N, Carpentier C, Letouzé E, Colin C, Mokhtari K, Jouvet A, Uro-Coste E, Martin-Duverneuil N, Sanson M, Delattre JY, Figarella-Branger D, de Reyniès A, Ducray F; POLA network.

Nature Communication 2016 Apr 19;7:11263.

Characteristics of gliomas in patients with somatic IDH mosaicism.

Bonnet C, Thomas L, Psimaras D, Bielle F, Vauléon E, Loiseau H, Cartalat-Carel S, Meyronet D, Dehais C, Honnorat J, Sanson M, Ducray F.

Acta Neuropathol Commun. 2016 Mar 31;4:31.

Pseudotumoral presentation of cerebral amyloid angiopathy-related inflammation.

Ronsin S, Deiana G, Geraldo AF, Durand-Dubief F, Thomas-Maisonneuve L, Formaglio M, Desestret V, Meyronet D, Nighoghossian N, Berthezène Y, Honnorat J, Ducray F.

Neurology 2016 Mar 8;86(10):912-9.

Neuronal networks in mental diseases and neuropathic pain: Beyond brain derived neurotrophic factor and collapsin response mediator proteins.

Quach TT, Lerch JK, Honnorat J, Khanna R, Duchemin AM.

World J Psychiatry 2016 Mar 22;6(1):18-30.

Inflammation during skeletal muscle regeneration and tissue remodeling: application to exercise-induced muscle damage management.

Chazaud B

Immunol Cell Biol. 2016 Feb;94(2):140-5.

Instructive role of M-CSF on commitment of bipotent myeloid cells involves ERK-dependent positive and negative signaling.

Carras S, Valayer A, Moratal C, Weiss-Gayet M, Pages G, Morlé F, Mouchiroud G, Gobert S.

J Leukoc Biol. 2016 Feb;99(2):311-9.

Chanson E, Bicilli E, Lauxerois M, Kauffmann S, Chabanne R, Ducray F, Honnorat J, Clavelou P, Rosenberg S.

Anti-NMDA-R encephalitis: Should we consider extreme delta brush as electrical status epilepticus?

Neurophysiol Clin 2016 Feb;46(1):17-25.

Henaine AM, Paubel N, Ducray F, Diebold G, Frappaz D, Guyotat J, Cartalat-Carel S, Aulagner G, Hartmann D, Honnorat J, Armoiry X.

Current trends in the management of glioblastoma in a French University Hospital and associated direct costs.

J Clin Pharm Ther. 2016 Feb;41(1):47-53.

A critical role for VEGF and VEGFR2 in NMDA receptor synaptic function and fear-related behavior.

De Rossi P, Harde E, Dupuis JP, Martin L, Chounlamountri N, Bardin M, Watrin C, Benetollo C, Pernet-Gallay K, Luhmann HJ, Honnorat J, Malleret G, Groc L, Acker-Palmer A, Salin PA, Meissirel C.

Mol Psychiatry. 2016 Dec;21(12):1768-1780