AMPKΑ1-LDH PATHWAY REGULATES MUSCLE STEM CELL SELF-RENEWAL BY CONTROLLING METABOLIC HOMEOSTASIS.
Marine Theret, Linda Gsaier, Bethany Schaffer, Gaëtan Juban, Sabrina Ben Larbi, Michèle Weiss-Gayet, Laurent Bultot, Collodet Caterina, Marc Foretz, Dominique Desplanches, Pascual Sanz, Zizhao Zang, Lin Yang, Guillaume Vial, Benoit Viollet, Kei Sakamoto, Anne Brunet, Bénédicte Chazaud & Rémi Mounier
Theret et al. identify LDH as a new functional target of AMPKα1 in MuSCs, where it is a direct regulator by which the oxidative phosphorylation/aerobic glycolysis balance can be shifted to control differentiation/self-renewal.
