We are pleased to welcome Marco SANDRI from the University of Padova in Italy, on June 18th.
He will give a seminar at 2 pm entitled: “Mitochondria-proteostasis-inflammation axis in muscle mass regulation and unhealthy ageing Mitochondria-proteostasis-inflammation axis in muscle mass regulation and unhealthy ageing ”

 📍The seminar will be in the Amphi 3, 3rd floor.

Abstract

While physical activity and exercise are beneficial for human health, sedentary life and inactivity are one of the major detrimental behaviors of industrialized societies that contribute to mortality and morbidity. Disuse, immobility, bedrest or unloading trigger weakness, fatigue onset and muscle loss. Despite the obvious decrease in muscle performance and quality of life, muscle wasting also contributes in rewiring whole-body metabolism leading to disease onset, morbidity and premature mortality. The underlying mechanisms that induce muscle loss and weakness during inactivity or in catabolic condition such as cancer growth are still unclear. Muscle wasting is driven and sustained by a transcriptional dependent program that controls the expression of rate limiting enzymes of different biological processes including but not exclusively ubiquitin proteasome and autophagy-lysosome, mitochondrial dynamics and bioenergetic, calcium homeostasis, ribosome and translation regulators, ER stress and Unfolded protein response, DNA damage response, chromatin modifiers and transcription factors. Here, the last insights that connect mitochondrial dysfunction, autophagy dysregulation, inflammation onset, DNA damage and gene expression activation with muscle mass regulation and unhealthy ageing will be presented.

Majors publications:

1) Tezze C, et al.. Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence. Cell Metab. 2017 Jun 6;25(6):1374-1389.

 2) Leduc-Gaudet JP, et al. MYTHO is a novel regulator of skeletal muscle autophagy and integrity. Nat Commun. 2023 Mar 2;14(1):1199.

3) Favaro G, et al.. DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass. Nat Commun. 2019 Jun 12;10(1):2576.

4) Franco Romero A, et al. C16ORF70/MYTHO promotes healthy aging in C.elegans and prevents cellular senescence in mammals. J Clin Invest. 2024 Jun 13;134(15):e165814.

5) Mansueto M. et al. Transcription Factor EB Controls Metabolic Flexibility During Exercise.  Cell Metab. 2017 Jan 10;25(1):182-196

6) Sartori R. et al. Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia. Sci Transl Med. 2021 Aug 4;13(605)